It is the method by which semen is directly placed in the uterus with the help of a catheter. The semen undergoes special media treatment and the process of centrifugation to achieve a better concentration of healthy and motile sperms, and to eliminate certain unnecessary and harmful components.
This treatment is often recommended as the first line treatment in cases of unexplained infertility. It is also in patients with:
- Mild endometriosis
- Infertility related to sexual problems
- Mild sperm abnormalities
- Door insemination to enhance the effectiveness this treatment
Ovulation Induction – IUI can be done in a natural cycle. However, to get better results, it is usually preceded by ovulation induction/ovarian stimulation, using appropriate fertility enhancing drugs. In order to attain 1 to 3 mature eggs, Tab clomiphene citrate or Inj — HMG/FSH are given to stimulate the growth of the follicles and cause ovulation at a predicted time.
Monitoring Treatment – It is done to measure the growth of follicles, individualize drug doses and prevent side-effects. Usually folliculometry is done by transvaginal ultrasound scanning (twice or thrice in a treatment cycle) or by measuring LH and E2 in blood samples.
Sperm Sample – It is prepared in the laboratory and given on the day of ovulation.
Insemination – The processed sperm sample is directly placed in the uterus using a catheter. It may be done over two consecutive days around the time of ovulation or after confirmed ovulation. The process is painless.
Pregnancy Testing – A blood test (beta hCG) or urinary pregnancy test is conducted after a period of 14 – 16 days of ovulation, to determine whether the women is pregnant or not.
IUI can only be performed in cases where the woman has at least one healthy Fallopian tube, and in which the sperm specimen prepares satisfactorily in the laboratory. We normally require the sperm to have at least 5 million moving sperm per ml to give IUI treatment a reasonable chance of working
IUI using Donor Sperm (Donor Insemination, DI, IUI/DI)
Donor sperm may be required in certain situations:
- women whose partners have no sperm in the ejaculate
- women who do not have a male partner and wish to conceive
- couples in whom there is a severe sperm problem and who do not wish to undergo the ICSI procedure.